Psychiatric medications, science, marketing, psychiatry in general, and occasionally clinical psychology. Questioning the role of key opinion leaders and the use of "science" to promote commercial ends rather than the needs of people with mental health concerns.
Tuesday, October 03, 2006
Yo Chuck, We Got Some Nonbelievers Out There (Corcept Plunges)
Remember Corecpt Therapeutics? They were testing mifepristone (aka RU-486 or Corlux) for psychotic depression. Well, again, things did not go exactly as planned. As indicated earlier, they found that the medication was no more efficacious than a placebo for depression in one trial, a result that was replicated by a second failed trial. One has to admire their ability to make excuses, as their press release states “As was the case in study 07 [the prior failed trial], there was an unusually high placebo response rate in Study 09.” When all else fails, blame the placebo! Two failed trials or not, Corcept marches on: They are enrolling patients in a third trial and plan to announce results in early 2007. Here at the CPP Blog, I will be watching anxiously. If they get one out of three, will the FDA give it a stamp of approval?
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